Pred-O3

Pred-O3 is a web server that compiles information about odorant molecules, their odors and their olfactory receptors (OR). The server integrates several tools to analyze the interactions between odorants, olfactory receptors and their physico-chemical properties. We freely give access to a compiled database of 5802 chemicals with known odors. The database contains 385 olfactory receptors (from human, mouse and rat species) for which at least one chemical-or interaction is known. There are 36016 known odorant-odor links and 2732 known odorant-OR interactions. The website proposes to search for olfactory receptors and/or odor annotated for a chemical (using its name or chemical structure). Also, through several tools, Pred-O3 gives the opportunity to predict olfactory receptors and odors associated to any small molecules using a graphical neural network methodology (GNN). Finally, the webserver predicts the ligand-olfactory receptor binding mode for a set of 1572 ORs.